Evaluating cell activation, killing and movement as a function of time

WORKFLOWS PLATFORM

Technology Platform

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The CellChorus platform is broadly applicable across a variety of cell types and applications. Whereas the life science researchers have benefitted from significant advances in single-cell analysis, CellChorus goes beyond static assaying. With TIMING, life sciences innovators can see literally watch new biology and gain new and unexpected understandings of how cells move, activate, kill and survive.

Example uses:

  • Evaluating MOA

  • Prioritizing CAR designs

  • Selecting optimal cytokines

  • Identifying appropriate cell subsets

  • ADCC assays for antibody development

  • CDC assays for antibody development

  • Metabolic profiling of manufactured cells

  • Evaluating responders and non-responders

  • Maintaining consistent manufacturing

Example applications:

  • Chimeric antigen receptor (CAR) T cells ‑ LINK

  • Antigen-specific T cells ‑ LINK

  • Monoclonal antibodies (mAbs) ‑ LINK

  • Natural killer (NK) cells ‑ LINK

  • T cell receptors (TCRs) ‑ LINK

  • Tumor-infiltrating lymphocytes (TIL) ‑ LINK

 

CellChorus provides comprehensive, dynamic analysis of single cells. Other methods of studying cellular activity lack the ability to integrate dynamic cellular behavior with molecular behavior at the single‑cell level. The company’s TIMING™ (Time-lapse Imaging Microscopy in Nanowell Grids) platform applies visual AI to evaluate cell activation, killing and movement as a function of time in order to maximize our understanding of cellular function, state and phenotype.

Learn more about the CellChorus workflows.

 

The company’s technology is protected in part by issued patents and pending patent applications, including US/10,746,736.