Example Videos
CellChorus provides comprehensive, dynamic analysis of single cells. Other methods of studying cellular activity lack the ability to integrate dynamic cellular behavior with molecular behavior at the single‑cell level. The company’s TIMING™ (Time-lapse Imaging Microscopy in Nanowell Grids) platform applies visual AI to evaluate cell activation, killing and movement as a function of time in order to maximize our understanding of cellular function, state and phenotype.
The videos below show single wells from arrays of 1000s of wells. Data from assays may include motility, time to contact, duration of synapse, time to target cell death, cellular morphology, and cytokine secretion, as well as subcellular morphology and trafficking.
COVID-19 Example (infectious diseases)
This video shows a single well from a chip comprised of 1000s of wells. In this well, a T cell with specificity for the Spike protein (position 424-433) of the novel coronavirus SARS-CoV-2 (COVID-19) from a recovered COVID-19 patient (“effector cell, GREEN) is shown exhibiting serial killing of target cells expressing the spike protein (YELLOW).
Contact (oncology)
This video shows a single well from a chip comprised of 1000s of wells. In this well, a CAR T cell ("effector" cell, BLUE) establishes contact with multiple "target" cells (RED).
Killing (oncology)
This video shows a single well from a chip comprised of 1000s of wells. In this well, there is one CAR T cell ("effector" cell, BLUE) and and multiple cancer cells ("target" cells, RED). Upon cell death ("apoptosis"), the targets fluoresce green, which makes them look orange.
Biomolecule Secretion (oncology)
This video shows an example of how the TIMING platform applies a functionalized bead (GREEN) to characterize interferon gamma secretion from a natural killer (NK) cell in one of 1000s of wells on a TIMING chip
Subcellular Resolution (oncology)
This video shows a single well from a chip comprised of 1000s of wells. In this well, dynamic lysosomal (green) behavior of a killer CAR+ T cell before and after contact with a tumor cell is observed.