2023 TIMING Grant Challenge

Submit by December 10, 2023

The CellChorus® TIMING™ platform evaluates individual cells and cell-cell interactions in thousands of nanowells over time. TIMING algorithms segment and classify cells in order to report single-cell data on readouts such as cell type, movement, morphology, contact dynamics (time to contact, duration of synapse), survival (spontaneous death, activation-induced cell death), potency (killing, serial killing), and biomolecule secretion (e.g., cytokines, extracellular vesicles). Cells of interest can be identified and retrieved for downstream analysis.

The platform has been featured in more than 20 peer-reviewed papers and presentations across a range of cell types and applications, including:

• understanding mechanism of action,

• engineering more effective therapies,

• prioritizing candidates for IND-enabling studies and clinical trials;

• identifying biomarkers of response to therapy; and

• evaluating potency and viability in manufacturing applications.

Example videos from the TIMING platform can be viewed on the videos page.

The Challenge seeks applicants with research, development and manufacturing projects that will benefit from dynamic single-cell analysis and present a significant innovation or advance relevant to human health. CellChorus will award up to ten TIMING assays conducted at the CellChorus Innovation Lab in Houston, Texas. The assays will be run in early 2024.

The Challenge will accept submissions from not-for profit researchers and investigators in commercial entities. CellChorus encourages submissions from investigators who are New Investigators, Early Stage Investigators, are members of underreprestented groups, and live or work in HUBzones. Submissions will be reviewed by CellChorus and a group of external reviewers. Terms and conditions can be found at cellchorus.com/terms-2023-grant-challenge.